Temperature Control after In-Hospital Cardiac arrest

The 2020 AHA guidelines recommend Targeted Temperature Management (TTM) for patients who remain unresponsive after cardiac arrest. The guidelines recommend using TTM for at least 24 hours.

A study by Wolfrum et al. published in Circulation in 2022 asked if Hypothermia (32-34°C) for 24 hours improves outcomes compared to normothermia in patients who achieved ROSC after IHCA?

Results:

💡Hypothermia did not improve 180-day survival (27% vs 29%)

💡Hypothermia did not improve good neurological outcome (23% vs 24%)

Because temperature management at lower temperatures is also correlated with an increased risk of side effects without any benefit in the TTM2 trial, a possible modification in the guidelines of temperature management is needed.

Disclaimer: This post is for educational purposes and is not intended as medical advice. While we strive for 100% accuracy, errors may occur, and medications or protocols may change over time.